Short-term outcomes of catheter ablation in atrial fibrillation in patients with metabolic syndrome

Abstract

Abstract Funding Acknowledgements Type of funding sources: None. Background Metabolic syndrome is widely discussed lately and it is consists of several components, which in turns exaggerates the development of the cardiovascular disease and rhythm disorders. Atrial fibrillation (AF) is considered one of the common type of heart rhythm disorders. Effects of metabolic syndrome components on outcomes of catheter ablation in AF remain poorly understood. Purpose Assess the influence of metabolic syndrome and its components on short-term outcomes of catheter ablation on atrial fibrillation. Methods We carried out a retrospective analysis of 120 patients who underwent atrial fibrillation ablation for the first time. 60 out of them were diagnosed with concomitant MetS (Group I) whereas 60 without MetS (Group II). Clinical outcomes, cardiovascular and all caused hospitalizations, procedural complications, AF recurrence, ischemic stroke were assessed. All endpoints were assessed at least 12 months after the catheter ablation. Results Median CHA2DS2-VASc were higher in Group I than Group II (2.2 (1-4) vs. 1.9 (1-3), P<0.05). Patients with MetS tended to have larger median diameter of left atrial than those without it (4.3 vs. 4.0, P<0.05). Cardiovascular and all cause hospitalizations did not differ in two groups (P>0.05). Median total radiofrequency duration (59.0 min vs. 61 min, P>0.05) and procedural complications (P>0.05) did not significantly differ between groups. AF recurrence in 12 months tended to be higher in Group I than Group II (9.0 vs.5.0, P>0.05). There were not statistically significant changes between groups in terms of ischemic stroke (1.0 vs. 1.0, P>0.05). Using multivariate regression analysis, among MetS components abdominal obesity (1.7 (1.1-2.1), P<0.05) hypertension (1.5 (1.1-1.9), P<0.05) were positively correlated with AF recurrence whilst median left atrial diameter was only correlated with hypertension (1.6 (1.1-2.0), P<0.05) after adjusting other risk factors. Conclusion AF recurrence in short-term period of catheter ablation in AF higher in patients with MetS. Further studies with large amount of patients are required along with assessment in long-term period.