Abstract

It is not clear for inhalation of ultrafine metal particles in air pollution to impair human health. In the study, we aimed to investigate whether short-term (4 weeks) inhalation of ultrafine zinc particles could deteriorate the cardiac and hemodynamic functions in rats of myocardial infarction (MI). MI was induced in Wistar rats through coronary artery ligation surgery and given an inhalation of ultrafine zinc particles for 4 weeks (post-MI 4 weeks, 4 days per week, and 4 h per day). Cardiac strain and strain rate were quantified by the speckle tracking echocardiography. The pressure and flow wave were recorded in the carotid artery and analyzed by using the Womersley model. Myocardial infarction resulted in the LV wall thinning, LV cavity dilation, remarkable decrease of ejection fraction, dp/dt Max, −dp/dt Min, myocardial strain and strain rates, and increased LV end-diastolic pressure, as well as impaired hemodynamic environment. The short-term inhalation of ultrafine zinc particles significantly alleviated cardiac and hemodynamic dysfunctions, which could protect from the MI-induced myocardial and hemodynamic impairments albeit it is unknown for the long-term inhalation.

Highlights

  • The adverse effects of ambient air pollution in the pathogenesis of acute and chronic diseases are recognized increasingly

  • We have previously shown that the inhalation of ultrafine zinc particles deteriorated local myocardial dysfunctions in the Left ventricle (LV) and the hemodynamic environment in peripheral arteries in rats of hypertension-induced heart failure with preserved ejection fraction (HFpEF) (Bing et al, 2020)

  • Half of the surviving myocardial infarction (MI) rats (n = 22) were exposed in the environment filled with ultrafine zinc particle (MI-Zn group, n = 22) using the same method as a previous study (Bing et al, 2020) while the rest were considered as the MI group (n = 22)

Read more

Summary

Introduction

The adverse effects of ambient air pollution in the pathogenesis of acute and chronic diseases are recognized increasingly. The ultrafine metal particles in air pollution have the possibilities to deteriorate the cardiovascular diseases (Birmili et al, 2006; Kodavanti et al, 2008; Wallenborn et al, 2008). Zinc is one of the main metal elements in air pollution in China (Ming et al, 2017; Abbreviations: HFpEF, Heart failure with preserved ejection fraction; HFrEF, Heart failure with reduced ejection fraction; STE, Speckle-tracing Echocardiography; BW, Body weight; HW, Heart weight; LV, Left ventricle; LAD, Left anterior descending artery; EF (%), Ejection fraction; FS (%), Fractional shortening; SV, Stroke volume; CO, Cardiac output; LVID;s, LV internal diameter in systole; LVID;d, LV internal diameter in diastole; ESV, End- systolic Volume of LV; EDV, End-diastolic Volume of LV; LVAW;s, LV Anterior wall in systole; LVAW;d, LV Anterior wall in diastole; LVPW;s, LV Posterior wall in systole; LVPW;d, LV Posterior wall in diastole; LVSP, LV systolic pressure; LVEDP, LV end-diastolic pressure; LCA, Left Carotid artery; SBP, Systolic blood pressure; DBP, Diastolic blood pressure; TAWSS, Time-average wall shear stress; OSI, Oscillating shear index; RRT, Relative residence time; WSS, Wall shear stress. It is worthwhile to study the effect of ultrafine zinc particles on cardiovascular diseases

Objectives
Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call