Short-term effect of preoperative sequential chemo-radiotherapy in the treatment of local bulky cervical cancer

Abstract

Objective To study the short-term effect of preoperative sequential chemoradiotherapy in the treatment of local bulky cervical cancer.Methods 67 cases of local bulky cervical cancer at stage Ⅰ b2-Ⅱ a (foci of cancer ＞ 4 cm) were randomly divided into study group (35 cases) and control group (32 cases).All patients received radiotherapy before operation.Study group was given TP model chemotherapy (paclitaxel + cisplatin) before and after radiotherapy,while control group was given eisplatin during radiotherapy.The short-term efficacy,pathologically complete regressiou (PCR) and toxicity of two groups were compared.Results The short-term efficacy of study group was 94.28％,and that of control group was 96.87％,without statistically significant difference betweeu two groups (P ＞ 0.05).There were obvious myelosuppressiou and reaction of digestive tract in two groups,which patients could suffered after treatment.Pathologically complete regression of study group was 14.29％,and that of control group was 15.62％,without statistically significant difference between two groups (P ＞ 0.05).Conclusions Preoperative sequential chemo-radiotherapy has equivalent efficacy to concurrent chemo-radiotherapy in the treatment of bulky cervical cancer.Preoperative sequential chemo-radiotherapy is more flexible in the treatment and will benefit more patients,worthy of promotion. Key words: Cervical cancer; Preoperative; Sequential chemo-radiotherapy; Concurrent chemo-radiotherapy; Curative effect; Side effect