SHORT-TERM BLOOD PRESSURE VARIABILITY WAS ASSOCIATED WITH COGNITIVE IMPAIRMENT IN HEART FAILURE WITH PRESERVED EJECTION FRACTION

Abstract

Objective: We previously reported that abnormal circadian blood pressure (BP) rhythm, a riser BP rhythm in which nocturnal BP exceeds awake BP was associated with cognitive impairment (CI) in heart failure (HF) patients. However, it is not clear that the short-term BP variability (BPV) was associated with cognitive impairment (CI) in HF patients. Design and method: We enrolled 416 hospitalized HF patients and performed ambulatory BP measurement (ABPM) and mini-mental state examination (MMSE). Cognitive impairment (CI) was defined as MMSE score <26. Results: HF with CI was significantly older, higher frequency of female, lower BMI, higer prevalence of HFpEF, higher LVM index than HF without CI. With regard to BP parameters, HF with CI was significantly higher BP variability than HF without CI. In multivariable logistic regression analysis to investigate the association between CI and BP variability, riser BP pattern and SD of sleep DBP (per 5mmHg) were significantly associated with CI (Odds ratio 2.58, 95%CI 1.51–4.43, p < 0.01, Odds ratio 1.45, 95%CI 1.12–1.87, p < 0.01, respectively). Conclusions: Nocturnal short-term BPV and riser BP pattern were associated with CI in HF patients. Hemodynamic abnormality during night should be paid attention not to impaired cognitive function in HF.