Short Term Alterations of Hormone Profile Following Oocyte Pick-Up in Women with Polycystic Ovarian Syndrome to Assess the Effect of Multiple Needle Entries Into the Ovarian Cortex and Stroma

Enis Ozkaya,Cigdem Abide Yayla,Semra Kayatas Eser,Belgin Devranoglu,Tayfun Kutlu,Ilhan Sanverdi

doi:10.21613/gorm.2017.713

Enis Ozkaya, Cigdem Abide Yayla + Show 4 more

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https://doi.org/10.21613/gorm.2017.713

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Abstract

Objective: Some hormonal alterations after ovarian diathermy have been proposed in previous studies. Based on this data, we aimed to analyze some hormone profile changes following oocyte pick-up in women with polycystic ovarian syndrome.Study Designs: A total of 50 women with polycystic ovarian syndrome underwent ovarian stimulation for IVF cycle with an indication of anovulatory infertility. Some hormone profiles with the insulin resistance were assessed before and after oocyte pick-up to (early in the morning before starting stimulation and repeated 1 month later from oocyte pick-up day) assess whether high number of needle entries into the ovarian cortex and stroma result in similar effect with the diathermy.Results: Comparison of some variables revealed significantly decreased HOMA-IR and serum total testosterone concentrations after intervention. Correlation analyses showed significant correlations between number of needle entries, change in HOMA-IR, baseline total testosterone level and change in AMH level. Conclusion: Our data showed significant metabolic and hormonal alterations following oocyte pick up consistent with the effect of ovarian diathermy in women with polycystic ovarian syndrome.

Highlights

Ovarian diathermy was introduced as a treatment option for anovulatory patients with polycystic ovarian syndrome (PCOS) [1,2]
Our hypothesis was based on the endocrine changes after ovarian diathermy and the data coming from the study by Hendriks et al, which proposed the mechanical movement/manipulation of the ovaries to be the main confounder for the ovarian response to diathermy procedure [9]
In a previous randomized study, ultrasound-guided transvaginal ovarian needle drilling was shown to have similar effect on endocrine profile in women with PCOS, no difference was observed between groups with ovarian diathermy and ovarian needle drilling in terms of rate of regular menses, hirsutism, acne, regular ovulation, pregnancy, serum luteinizing hormone (LH), FSH, FSH/LH ratio and testosterone levels [11]

Summary

RESULTS

Comparison of some variables revealed significantly decreased HOMA-IR and serum total testosterone concentrations after intervention. Correlation analyses showed significant correlations between number of needle entries, change in HOMA-IR, baseline total testosterone level and change in AMH level

CONCLUSION

Introduction

Material and Method

Results

Discussion