Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study.

Victor Barbosa Ribeiro,Daiana Cristina Chielli Pedroso,Cristiana Libardi Miranda Furtado,Gislaine Satyko Kogure,Rosana Maria Dos Reis,Iris Palma Lopes,Hugo Celso Dutra De Souza,Rodrigo Tocantins Calado,Barbara Aparecida Santana,Rui Alberto Ferriani

doi:10.3390/ijerph182111274

Abstract

Metabolic and hormonal outcomes of polycystic ovary syndrome (PCOS) have implications on telomere biology and physical activity may prevent telomere erosion. We sought to observe the effects of continuous (CAT) and intermittent (IAT) aerobic training on telomere length, inflammatory biomarkers, and its correlation with metabolic, hormonal, and anthropometric parameters of PCOS. This randomized controlled clinical trial study included 87 PCOS randomly stratified according to body mass index (BMI) in CAT (n = 28), IAT (n = 29) and non-training control group (CG, n = 30). The exercises were carried out on a treadmill, three times per week for 16 weeks. The participants’ anthropometric characteristics and biochemical and hormonal concentrations were measured before and after aerobic training or observation period, as the telomere length that was evaluated using quantitative real-time PCR. Four months of aerobic exercises (CAT or IAT) did not alter telomere length and inflammatory biomarkers in PCOS women. Obesity index as BMI and waist circumference (WC), and inflammatory biomarkers negatively affect telomeres. The hyper-andro-genism measured by testosterone levels was reduced after both exercises (CAT, p ≤ 0.001; IAT, p = 0.019). In particular, the CAT reduced WC (p = 0.045), hip circumference (p = 0.032), serum cholesterol (p ≤ 0.001), and low-density lipoprotein (p = 0.030). Whereas, the IAT decreased WC (p = 0.014), waist-to-hip ratio (p = 0.012), free androgen index (FAI) (p = 0.037). WC (p = 0.049) and body fat (p = 0.015) increased in the non-training group while total cholesterol was reduced (p = 0.010). Booth exercises reduced obesity indices and hyperandrogenism on PCOS women without changes in telomere length or inflammatory biomarkers.

Highlights

Polycystic ovary syndrome (PCOS) is a multifactorial heterogeneous endocrine disorder where the main characteristic behind this syndrome is chronic anovulation due toInt
Considering the importance of the practice of physical exercise in women with polycystic ovary syndrome (PCOS), we investigate the effects of two aerobic physical training protocols, continuous (CAT) and intermittent (IAT), on telomere length and its correlation with metabolic, hormonal, and anthropometric parameters in women with PCOS
We previously reported that physical resistance training (PRT) improved hyperandrogenism, reproductive function, and body composition in women with PCOS, with no changes in body mass index (BMI) or metabolic parameters of PCOS [8]

Summary

Introduction

Polycystic ovary syndrome (PCOS) is a multifactorial heterogeneous endocrine disorder where the main characteristic behind this syndrome is chronic anovulation due toInt. Infertility and metabolic complications, such as dyslipidemia, hypertension, abnormal glucose metabolism, insulin resistance (IR), and obesity, are often present in PCOS [2], which increased the risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) [3,4]. This variability of phenotypes associated with PCOS depends on ethnicity and directly interferes with the prevalence of this syndrome, which affects between 5 and 16% of women of reproductive age [2]

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