Abstract
(5S)-5-Benzyloxy-5-ethyl-6-oxo-5,6-dihydro-2H-pyran-3-carboxylic acid, the protected E-ring moiety of (S)-camptothecin, has been rapidly prepared in enantiomerically enriched form (98% ee) through enolate conjugate addition to a β-bromo methacrylate derivative, followed by enzymatic resolution with PLE.
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