Abstract
Adults with short stature have been previously reported to have increased risk of cardiovascular events and hyper-LDL-cholesterolemia. We aimed to assess the association between height and lipid profiles among Korean adolescents and adults. We analyzed data from the Korea National Health and Nutrition Examination Survey from 2007 to 2015, from 37,889 individuals (aged 12–59 years). In adolescents, total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) levels had profound associations with height in both boys and girls, while high density lipoprotein-cholesterol (HDL-C) levels had an inverse association with height only in boys. Height was inversely associated with TC, triglycerides (TG), and LDL-C concentrations in men and women and positively correlated with HDL-C concentration in women. In boys, the odds ratios (ORs) for hypercholesterolemia, hypertriglyceridemia, hyper-LDL-cholesterolemia were higher for shorter subjects (ORs = 2.38~7.01), while only the OR of hyper-LDL-cholesterolemia was significantly higher in girls with short stature (OR = 3.12). In adults, the ORs for hypercholesterolemia, hypo-HDL-cholesterolemia, and hyper-LDL-cholesterolemia were significantly higher in short subjects than in tall subjects after controlling for covariates (ORs = 1.50~2.61). Also, short men showed significantly higher ORs for hypertriglyceridemia (OR = 1.85) than tall men. Short stature was significantly associated with adverse lipid profiles in both adolescents and adults.
Highlights
Dyslipidemia is one of the major established risk factors for CVD; treatment of dyslipidemia ameliorates the risk of CVD, and dyslipidemia has been reported to be inversely associated with adult height[5,6,7]
The present study found that short stature has a significant inversely association with dyslipidemia in both Korean adolescents and adults
The risk of hypercholesterolemia, hypertriglyceridemia, and hyper-LDL-cholesterolemia was linked with height in boys, while only hyper-LDL-cholesterolemia was significantly related to height in girls
Summary
Dyslipidemia is one of the major established risk factors for CVD; treatment of dyslipidemia ameliorates the risk of CVD, and dyslipidemia has been reported to be inversely associated with adult height[5,6,7]. CVD usually develops in later life, it is well known that the accumulation of intimal fatty streaks, which are early atherosclerotic lesions, develops from childhood in association with dyslipidemia. The identification of risk factors for dyslipidemia in children and adolescents is essential for its early detection and management and the consequent prevention of CVD in later life[8]. Few studies have been conducted on the relationship between height and blood lipid concentrations in children and adolescents[10,11,12,13,14,15]. There have been no studies on the association of dyslipidemia and height in Korean adolescents and adults. We aimed to assess the association between height and serum lipid profile in Korean adolescents and adults using data from the Korean National Health and Nutrition Examination Survey (KNHANES)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
