Abstract
Updated Sydney System. In 10 patients with marked antral 1M and 10 without 1M, Ki-67 lavelling index (LI) in the antral mucosa was assessed. The immunostaining was performed using MIB-I antibody (Immunotech, Marseille, France) and by the avidin-biotin method with microwave retrieval. LI was calculated by counting MIB-I-positive cells in the entire gastric pits longitudinally sectioned and was expressed as a percentage ratio of the total cells in a gastric pit. Results: Table shows the number of patients in each category of change after the therapy. There was no significant difference in the grade of atrophy or 1M between before and after the therapy. After eradication, Ki-67 LI in the antral mucosa without 1M decreased significantly (from 34 to 25%, p<0.05), but that in the 1M did not change (from 36 to 39%). Conclusions: During 1-4 years after H. pylori eradication, regression or improvement of atrophy was found in 40% of patients. No significant regression of 1M, however, was found. 1Mkeeps proliferating after eradication of H. pylori.
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