Abstract
Endocrine-disrupting chemicals (EDCs) have recently attracted the interest of public health organizations, motivating substantial research to identify their effect on human health. Dysfunctions in endocrine system activities can raise the risk of a wide range of disorders, including cardiovascular disease, type 2 diabetes, cancer, and reproductive disorders. Given that bisphenol A (BPA) and other bisphenols are considered to raise the risk of these disorders primarily through activating oxidative and inflammatory pathways, it has been hypothesized that dietary substances with anti-inflammatory and antioxidant capabilities may mitigate their negative effects. Polyphenols have been analyzed for their capacity to protect against the negative effects of BPA and phthalates since they are some of the most well-established substances with such properties. Given the importance of defining the relationship between bisphenols and human health and discovering approaches to combat the harmful effects they may cause, this review will summarize the evidence on dietary exposure to bisphenols, how they influence disease risk, the basis for and available research on how polyphenols mitigate their adverse effects, gaps in knowledge, and future research suggestions.
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