Abstract
We examined the relationship between Short Physical Performance Battery (SPPB) and clinical and laboratory factors and the effect of sarcopenia and sarcopenic obesity (SO) on clinical and laboratory factors for cardiovascular disease (CVD) inpatients. CVD male (n = 318) and female (n = 172) inpatients were recruited. A stepwise multiple-regression analysis was performed to predict total SPPB scores and assess clinical and laboratory factors (physical characteristics, functional and morphological assessments, etc.). Each test outcome were compared among sarcopenia, SO and non-sarcopenic groups. To predict total SPPB scores, the predicted handgrip, Controlling Nutritional Status score, % body fat, anterior mid-thigh muscle thickness, standing height and systolic blood pressure were calculated for males and anterior mid-thigh MTH, BMI, knee extension and fat mass were calculated for females. There were no differences in blood pressure, total SPPB scores and functional assessments between sarcopenia and SO groups for CVD male and female inpatients. In conclusion, the physical performance of CVD inpatients can be predicted by nutritional, functional, clinical and anthropometric variables, regardless the gender and the presence of sarcopenia. Furthermore, the presence of sarcopenia has a negative effect on the clinical and laboratory factors, but there is a difference in impact between sarcopenia and SO regardless the gender.
Highlights
Cardiovascular disease (CVD) is a major contributor to the global burden of diseases[1,2]
The proportion of sarcopenic obesity (SO) assessments for cardiovascular disease (CVD) patients was larger in females than in males (Fig. 2)
The main findings of this study were as follows: First, anterior mid-thigh muscle thickness (MTH) can predict total Short Physical Performance Battery (SPPB) scores for both CVD male and female inpatients
Summary
Cardiovascular disease (CVD) is a major contributor to the global burden of diseases[1,2]. The Short Physical Performance Battery (SPPB), a brief performance battery based on a timed short distance walk, repeated chair stands, and a set of balance tests, is a validated assessment tool for measuring lower extremity function that is widely used in both clinical and research settings[6,7] This means of assessment offers relative ease of use, perceived potential for implementation in clinical practice, and a good relationship with physical activity levels and walking disability in a variety of patients or older adults. The assessment of body composition is commonly performed by quantifying fat mass and fat-free mass (e.g., skeletal muscle mass) components These components are often utilized to assess the risk for adverse health outcomes in a variety of conditions[10]. Recent clinical studies have focused on health outcomes in sarcopenic obesity as well as sarcopenia[15,16]
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