Abstract
The recent discovery of the molecular identity of the mitochondrial Ca2+ uniporter complex (mtCUC) has led to rapid progress in characterizing the mechanisms of mitochondrial Ca2+ influx and its influence on mitochondrial and cellular functions. Indeed, MCU protein, a pore-forming subunit of mtCUC, resides at the inner mitochondrial membrane and regulates the primary Ca2+ influx pathway in various cell types. Here, we report that the human MCU gene produces a shorter variant (termed MCU-S) compared to the transcript encoding the canonical MCU protein (renamed as MCU-L).
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