Short-latency auditory evoked potentials in the monkey. II. Intracranial generators

Abstract

The generators of the short-latency auditory evoked potentials (SLAEPS) in the monkey have been defined by intracranial mapping from cochlea to auditory cortex. SLAEP components other than 1a and the slow negatively (SN) following wave 7 derive from compound action potentials propagated in subcortical auditory pathways. The component generators are complex due to the presence of two bursts of activity in the eighth nerve, to the fact that the ascending auditory fibers both synapse on and bypass specific relay nuclei, and to the differences in orientation of segments of the auditory pathways. Most SLAEP components recorded at the surface reflect the summation of activity from multiple generators. However, much of the activity seen within subcortical structures cannot be traced to the surface of the brain. Component 1a is identified with the cochlea summating potential, while 1b reflects the initial afferent volley in the distal portion of the eighth nerve. Component 2 represents the initial depolarization of the eighth nerve terminals within the ipsilateral cochlear nucleus. Component 3h reflects the second volley of activity in the distal portion of the eighth nerve and the outflow of the cochlear nucleus which decussates in the trapezoid body. Component 3v represents the initial cochlear nucleus outflow volley ascending the lateral lemniscus. Component 4 principally reflects the second volley activity within the eighth nerve terminals, and outflow from the ipsilateral superior olivary complex ascending in thet lateral lemniscus, with a possible contribution from activity in the contralateral CNC. Component 5 represents the outflow of the contralateral superior olivary complex ascending in that lateral lemniscus. Component 6 reflects another volley from the ipsilateral superior olivary complex ascending in that lateral lemniscus, as well as outflow from both inferior colliculi propagating in their brachii. The generators of components 7 are the most complex encountered, representing volleys in both lateral lemnisci, activity of the contralateral inferior colliculus, and activity in both auditory radiations. A component that follows wave 7, seen best in mastoid-to-mastoid recording linkage, represents outflow from both inferior colliculi propagating in their brachia. Components 8 and 9 principally reflect propagated action potentials in the auditory radiations bilaterally, with an additional contribution from activity of both inferior colliculi. The SN mainly represents volume-conducted postsynaptic potentials from both inferior colliculi and cochlear nuclei.