Short information: Bacterial meningitis in very low birthweight infants in Korea from 2013-2016.

Abstract

Neonatal bacterial meningitis (BM) has an incidence of 0.2-0.4 per 1,000 births and a mortality rate of 20-25%. Data from the Korean Neonatal Network (KNN) were evaluated to study the incidence, mortality, and risk factors associated with BM in very-low-birthweight (VLBW; <1,500 g) infants. We analyzed KNN data from 2013-2016 collected from 70 neonatal units. The incidence of BM in VLBW infants was 40 out of 8,263 (0.5%). The 40 infants with BM had a mean gestational age of 27.1 ± 2.0 weeks and a mean birthweight of 1,036.8 ± 220.0 g. Mean age at diagnosis was 51.5 ± 38.3 days (range, 1-171). Infants with BM were divided into two groups: Group 1 (onset age ≤ 28 days) and Group 2 (onset age > 28 days). Coagulase-negative Staphylococcus (CONS) was the most common pathogen underlying meningitis in 11 of 40 cases (28%). BM co-occurred with bacteremia in 14 of 40) of cases (35%); bacteremia was significantly more common in Group 1 than Group 2 (P < 0.05). Seizure and intraventricular hemorrhage (≥grade 3) were significantly more prevalent in Group 2 than Group 1 (P < 0.05). The mortality rate of infants with BM was 4 out of 40 (10%), which was significantly lower than that of VLBW infants without BM (1,152/8,223, [14%]; P < 0.05). The incidence of BM in VLBW infants was high, but the mortality rate was low. CONS was the most common pathogen of BM in VLBW infants.