Abstract
Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon like peptide‐1 (GLP‐1) are important incretins, facilitating release of insulin from pancreatic islets. In addition, these peptides affect satiety and metabolism. Our aim was to study effects of GIP and GLP‐1 on duodenal mucosal bicarbonate secretion in fed and food‐deprived animals. Glucagon like peptide‐2 (GLP‐2) is not an incretin but was tested for comparison. Methods: Lewis x Dark Agouti rats had free access to water and, unless fasted overnight, free access to food. Animals were anesthetized (thiobarbiturate, 120 mg/kg) and a segment of proximal duodenum with intact blood supply cannulated in situ. Mucosal bicarbonate secretion (pH stat) was continuously recorded and peptides were administered to the duodenum by close intra‐arterial infusion. Results: Intra‐arterial infusion of GIP (60‐600 pmol/kg, h) caused dose‐dependent increases in duodenal bicarbonate secretion in fed animals (p<0.01) but not in fasted animals (p>0.05). At a higher dose (6000 pmol/kg, h), GLP‐1 induced a slight increase (p<0.05) in secretion. GLP‐2 did not affect the duodenal secretion. Conclusions: GIP and to a smaller extent GLP‐1, stimulate duodenal bicarbonate secretion in fed but not in overnight fasted rats. Studies of intestinal secretion may require particular evaluation with respect to feeding status.Supported by the Swedish Research Council
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