Short communication: Influence of the muscle hypertrophy mutation of the myostatin gene on milk production traits and milk fatty acid composition in dual-purpose Belgian Blue dairy cattle

Abstract

The objective of this study was to estimate genetic effects for the muscle hypertrophy mutation (mh) of the myostatin gene for conventional milk production traits and for milk fatty acid composition in dual-purpose Belgian Blue dairy cows. For the present study, only cows from a single herd, in which genotype frequencies were as balanced as possible (0.266 for +/+, 0.523 for mh/+, and 0.211 for mh/mh), were chosen to avoid confounding between herd and genotype effects. A total of 109 cows with 3,190 test-day records for fat, protein, and milk yields and 1,064 test-day records for saturated and monounsaturated fatty acids were used for the calculations. Variance component and gene effect estimations were performed via expectation-maximization REML and BLUP methods, respectively, using a multi-trait mixed test-day model with an additional fixed regression on the muscle hypertrophy genotype. Results showed that one copy of the wild-type “+” allele led to a significant additive effect of 26.35 g/d for fat yield. Significant dominance effects of 23.22 g/d for protein yield and 30.28 g/d for fat yield were also observed. In contrast, a nonsignificant trend was observed in favor of lower saturated fatty acid contents in milk for one copy of the mutant “mh” allele. Concerning milk, fat, and protein yields, our results confirmed literature results indicating a superior effect of the “+” allele compared with the mutant allele. Therefore, the selection of the “+” allele has the potential to increase conventional milk production traits in the dual-purpose Belgian Blue breed. However, when focus is given to milk fatty acid profile, a possible antagonistic effect between the benefit of the “+” allele for higher milk production and the “mh” allele for reduced saturated fatty acid content in milk should be confirmed in further studies.