Abstract

AbstractIbogamine (11b) was synthesized starting from the vinyl sulfone 3. Addition of organocuprate reagents to 3 furnished 2a–d with high stereoselectivity. Only products from the syn addition of the cuprate reagents could be detected. Functional group transformations provided 7a,b the key intermediates for the synthesis of (±)‐21‐noribogamine (11a) and (±)‐ibogamine (11b).

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call