Abstract
AbstractA plant‐based straightforward and short four‐step synthesis of cholesterol starting from commercially available diosgenin is reported. This offers a large‐scale production of highly needed GMP‐grade cholesterol, which is part of the lipid cocktail for the assembly of effective mRNA‐based vaccines against the COVID‐19 pandemic. These lipids are formulated into the delivery system of the mRNA fragments by forming Lipid Nano Particles (LNP) that introduce the mRNA into the cells. Cholesterol plays a crucial role because it stabilizes LNP and facilitates endosome escape of the mRNA into the cytosol.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
