Abstract
Objective To investigate the clinical efficacy of applicating TIPS treatment of cirrhosis and portal hypertension caused refractory pleural effusion and ascites. Methods In the retrospective study, 427 consecutive patients with cirrhosis and portal hypertension caused refractory pleural effusion and ascites who have received TIPS treatment were followed-up and analyzed. Results The success rate of TIPS were 99.30% (427/430) and there were 85.25% (364/427) patients whose symptoms of pleural effusion and ascites were completely disappeared post-TIPS, besides 8.43% (36/427) were effective and 6.32% (27/427) were ineffective; Cumulative rate of shunt dysfunction post-TIPS were 3.98% (17/427), 18.49% (76/411), 27.39% (103/376), 37.43% (125/334), 46.01% (121/263) and 58.54% (120/205) respectively in 6 months, 1 year, 2 years, 3 years, 4 years and 5 years; The survival rate were 99.53% (425/427), 96.59% (397/411), 87.23% (328/376), 81.14% (271/334), 73.38% (193/263), 57.56% (118/205) respectively in 6 months, 1 year, 2 years, 3 years, 4 years and 5 years. No deaths associated with TIPS-operation in the study. Conclusions TIPS should be considered a safe, effective and conventional therapy for cirrhosis and portal hypertension caused refractory pleural effusion and ascites of such disorders, worthy of promotion. Key words: Liver cirrhosis; Transjugular intrahepatic portosystemic shunt; Ascites; Efficacy
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