Abstract
A shock‐wave‐based biolistic device has been developed to deliver DNA/drug‐coated micro‐projectiles into soft living targets. The device consists of an Nd:yttrium aluminum garnet laser, equipped with a suitable optical setup and a thin aluminum (Al) foil (typically 100‐μm thick). The powdered vaccines to be delivered are deposited on the anterior surface of the foil and the posterior surface of the foil is ablated using the laser beam. The ablation launches a shock wave through the foil that imparts an impulse to the foil surface, due to which the deposited particles accelerate to high velocities that are sufficient to enable them to penetrate soft targets. The device has been tested for in vivo DNA delivery by delivering plasmid‐coated, 1‐μm size, gold (Au) particles into onion and tobacco cells. The GUS activity was detected in the onion and tobacco cells after the addition of an artificial substrate. The present device is totally nonintrusive in nature and has a potential to get miniaturized to suit the existing medical procedures for drug delivery.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
