Abstract
High‐fat diets induce an expansion of the adipose tissue (AT) which is an important source of adipokines and pro‐inflammatory cytokines. The purpose of this study was to evaluate the effects of a shift from a high‐fat diet to high‐carbohydrate (CHO) diet on the blood levels of adipokines and pro‐inflammation cytokines in mice fed a high‐fat diet. Six‐week‐old male C57BL/6 mice were fed a high‐fat diet (40% of the total calories) for 9 weeks and then the diet was shifted to a high‐CHO diet (70% of the total calories) for 3 weeks. Body weight and epididymal adipose tissue weight as well as blood lipid levels were measured. The serum levels of adipokines and pro‐inflammatory cytokines were analyzed. Shifting the diet from high fat to high CHO significantly decreased body weight and epididymal fat. The blood levels of lipids (TG, total‐chol, and LDL‐chol) decreased. The blood levels of leptin and resistin significantly decreased after the diet was shifted to a high‐CHO diet however, the adiponectin concentrations did not changed. The serum levels of IL‐6 and TNF‐alpha. decreased by the high‐CHO diet. The serum levels of IL‐13 increased by the high‐CHO diet. Conclusively, reduction of body weight and epididymal fat through shifts from a high‐fat diet to a high‐carbohydrate diet effectively improved low‐grade inflammation states in mice fed a high‐fat diet.
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