Abstract
AimsThere is increasing evidence linking a shift work schedule with various adverse health effects. The present study aimed to examine the relationship between shift work and the metabolic syndrome (MetS) in male steel workers, and also the possible mechanism of shift work-related metabolic derangements.MethodsA total of 1732 men aged 42 ± 8 years were enrolled in this cross-sectional study, including 862 day workers and 870 shift workers. Circulating levels of resistin were measured by ELISA using monoclonal specific antibodies.ResultsThe shift workers had higher rates of MetS and its components (central obesity, hypertension, and hypertriglyceridemia) than the day workers. In multiple logistic regression analysis, shift work was independently associated with MetS. In further analysis, the shift workers had elevated circulating levels of resistin (13 ± 10 vs. 10 ± 7 ng/mL) and total white blood cell (WBC) count (6.865 ± 1.819 vs. 6.304 ± 1.547 109/L) than the day workers. In addition, both resistin level and total WBC count were significantly associated with shift work, MetS, and its components (body mass index, fasting glucose, triglyceride, and high-density lipoprotein-cholesterol levels), and plasma resistin levels were significantly associated with total WBC count (β = 0.34, p < 0.0001).ConclusionShift work was independently associated with MetS in male steel workers. Resistin and WBC count were associated with shift work-related metabolic derangements.
Highlights
Shift work is defined that takes place on a schedule outside the traditional 9 a.m.–5 p.m. day
Shift work may be responsible for increased body fatness and inflammatory markers, higher blood pressure levels, and chronic low-grade inflammation to play an important role in the development of metabolic syndrome (MetS) [3, 12,13,14,15,16]
The shift workers had a lower level of high-density lipoprotein cholesterol (HDL-C) than the daytime workers (Table 2)
Summary
Shift work is defined that takes place on a schedule outside the traditional 9 a.m.–5 p.m. day. It can involve evening or night shifts, early morning shifts, and rotating shifts [1]. The prevalence of MetS is increasing globally, including Taiwan. The components of MetS including dyslipidemia, dysglycemia, high blood pressure, and being overweight/obese tend to cluster together, and they are. Shift work may be responsible for increased body fatness and inflammatory markers, higher blood pressure levels, and chronic low-grade inflammation to play an important role in the development of MetS [3, 12,13,14,15,16]
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