Abstract
In 2010, Tian et al. reported the development of a new, relatively sensitive method of the chemical analysis of various surfaces, including buried interfaces (for example the surfaces of solid samples in a high-pressure gas or a liquid), which makes it possible to analyze various biological samples in situ. They called their method shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS). SHINERS spectroscopy is a type of surface-enhanced Raman spectroscopy (SERS) in which an increase in the efficiency of the Raman scattering is induced by plasmonic nanoparticles acting as electromagnetic resonators that locally significantly enhance the electric field of the incident electromagnetic radiation. In the case of SHINERS measurements, the plasmonic nanoparticles are covered by a very thin transparent protective layer (formed, for example, from various oxides such as SiO2, MnO2, TiO2, or organic polymers) that does not significantly damp surface electromagnetic enhancement, but does separate the nanoparticles from direct contact with the probed material and keeps them from agglomerating. Preventing direct contact between the metal plasmonic structures and the analyzed samples is especially important when biological samples are investigated, because direct interaction between the metal nanoparticles and various biological molecules (e.g., peptides) may lead to a change in the structure of those biomolecules. In this mini-review, the state of the art of SHINERS spectroscopy is briefly described.
Highlights
When nanoparticles formed from metals with a negative real and small positive imaginary dielectric constant interact with electromagnetic radiation, a collective oscillation of surface conduction electrons called surface plasmons is induced (Aroca, 2006)
From the practical point of view, what is most important is the enhancement of the efficiency of Raman scattering generation induced by the plasmonic systems–this effect is called surface-enhanced Raman scattering (SERS)
In this mini-review, we briefly present current advances in the synthesis of shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) nanoresonators, and new applications of SHINERS spectroscopy
Summary
In 2010, Tian et al reported the development of a new, relatively sensitive method of the chemical analysis of various surfaces, including buried interfaces (for example the surfaces of solid samples in a high-pressure gas or a liquid), which makes it possible to analyze various biological samples in situ They called their method shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS). Preventing direct contact between the metal plasmonic structures and the analyzed samples is especially important when biological samples are investigated, because direct interaction between the metal nanoparticles and various biological molecules (e.g., peptides) may lead to a change in the structure of those biomolecules In this mini-review, the state of the art of SHINERS spectroscopy is briefly described
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