Abstract
THE margin between dermis and epidermis is one natural–splitting layer of human skin. By the gentle tryptic digestion of flat human skin slices for a length of time depending on their thickness, it is possible to disengage the epidermis in the form of an intact sheet uncontaminated by mesodermal elements. There is histological1 and clinical2 evidence that the elastic fibres of the so–called “basement membrane” play an important part in anchoring the epidermis to the underlying tissue. Elastic fibres are known to be rapidly and specifically dissolved by trypsin.
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