Shear augmented microvascular solute transport with a two-phase model: Application in nanoparticle assisted drug delivery

Abstract

Solutal dispersion phenomena are associated with the nanoparticle-based drug delivery in the cardiovascular system to cure cardiovascular disorder. In the present problem, we explored the solutal transport for an unsteady blood flow through a microvessel with wall absorption. The rheology of blood is characterized by a two-fluid model similar to three-layer flow, namely, the core region, the intermediate region, and the peripheral region. The nature of the blood is considered as Casson fluid near the axis of the microvessel and Newtonian fluid close to the wall of the microvessel (at the intermediate and peripheral region). The peripheral region and the wall of the microvessel are permeable, and the permeability of the microvessel wall is defined by the Darcy–Brinkman model. The permeability of the inner surface of the microvessel is subjected to a slip condition at the surface. The stress-jump condition acts at the interface of the intermediate and peripheral region. The impact of the absorption parameter, velocity slip, yield stress, stress jump constant, nanoparticle volume fraction, and permeability on the velocity, exchange coefficient, convection coefficient, dispersion coefficient, and mean concentration is shown. It observed that the mean concentration boosts by the yield stress, nanoparticle volume fraction, and absorption parameters. The stress jump constant and permeability boost the convection coefficient, while the dispersion coefficient is restricted by the yield stress and absorption parameter.