Abstract
Using a membrane filter method the role of Sexual Hormone Binding Globulin (SHBG) during female sexual development was investigated. Details on the method and values in boys have already been reported. Before puberty there is no sex difference in SBHG levels. With the onset of puberty, SHBG levels progressively decline in males, but do not show significant changes in females (range PI to P4 8.8-7.0 ug/ ml) until stage P5 when a significant decline (3.7 ug/ml) is observed. In adult females SHBG values show marked scatter resulting in a higher mean concentration. The post-pubertal scatter found in this study might be related to the cyclic fluctuations in the plasma concentration of sexual steroids, and therefore, to changes in the oestrogen to androgen ratio.
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