Abstract
Huntington’s disease is a progressive movement disorder caused by a CAG repeat expansion in the HTT gene, which encodes the protein huntingtin (1). Most individuals with Huntington’s disease exhibit psychiatric symptoms and cognitive dysfunction (1). In this issue of Biological Psychiatry, Ellis et al. (2) have examined the genetic relationship between psychiatric and cognitive symptoms in patients with Huntington’s disease and related disorders and traits in the broader population. In a large cohort of individuals with Huntington’s disease, the authors calculated polygenic risk scores (PRSs) from large genome-wide association studies (GWASs) of psychiatric, neurological, and cognitive traits.
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