Shared Genetic Etiology Between Eoe and Other Allergic Diseases

Abstract

FEBRUARY 2015 AB40 Abstracts S A T U R D A Y 123 Adult Eosinophilic Oesophagitis: A UK Based Case Series Efrem Eren, MBBS, MRCP, FRCPath, PhD, Tak Chin, William Rae, BSc, BM, MRCP, Syed H. Arshad, DM, FRCP, Peter H. Howarth, MD, Anthony Williams, Elena Salagean, SpR, Bryan N. Fernandes, MD, Ramesh Kurukulaaratchy, Carina Venter, PhD, RD; Southampton General Hospital, UK, Southampton, United Kingdom, Southampton, University Hospital Southampton, Southampton, United Kingdom, The David Hide Asthma and Allergy Research Centre, United Kingdom, University of Southampton, United Kingdom, Southampton General Hospital, Southampton, United Kingdom, University of Southampton, University Hospital of NHS Foundation Trust, United Kingdom, University of Southampton, Southampton, United Kingdom, University of Portsmouth, United Kingdom. RATIONALE: Adult onset Eosinophilic Oesophagitis (EoE) presents frequently to the allergy clinics in the UK. However, no study to date has attempted to describe these patients. . This case series set out to clinically characterise adults patients with EoE seen over the past four years in a tertiary care center in the UK. METHODS: We screened Allergy/Immunology clinic lists and the edocument systems at Southampton General Hospital (SGH) for patients given a diagnosis of EoE since 2010. RESULTS: Thirty six patients were identified with a diagnostic label of EoE. They were predominantly male (77.8%; 28/36) with an age range of 19 – 71 years. The majority (61%, 22/36) suffered from other atopic conditions/or showed a positive total IgE level and suspected a wide range of potential foods triggers. Interestingly, patients often considered food that are difficult to swallow such as meat, chicken and starchy food as the cause of their problems. SPT and specific IgE tests were not helpful in identifying offending foods. As expected the majority (58.3%; 21/36) were sensitised to aero-allergens with 14 being sensitised to tree/birch pollen. Dietary interventions varied widely between these patients, ranging from elemental diets, 6 food elimination diets to test directed diets. CONCLUSIONS: Male sex and atopy were found to be primary characteristics, but age did not influence the diagnosis. A wide range of foods are suspected to trigger EoE pathology in adults, and dietarymeasure seems to vary greatly. Studies are needed to identify which foods are implicated in adult EoE in the UK.