Shape Tailored Magnetic Nanorings for Intracellular Hyperthermia Cancer Therapy

Carlos S B Dias,Flávio Garcia,Talita D M Hanchuk,Mateus B Cardoso,Heberton Wender,Jörg Kobarg,André L Rossi,Willian T Shigeyosi,Marcelo N Tanaka

doi:10.1038/s41598-017-14633-0

Abstract

AbstarctThis work explores a new class of vortex/magnetite/iron oxide nanoparticles designed for magnetic hyperthermia applications. These nanoparticles, named Vortex Iron oxide Particles (VIPs), are an alternative to the traditional Superparamagnetic Iron Oxide Nanoparticles (SPIONs), since VIPs present superior heating power while fulfilling the main requirements for biomedical applications (low cytotoxicity and nonremanent state). In addition, the present work demonstrates that the synthesized VIPs also promote an internalization and aggregation of the particles inside the cell, resulting in a highly localized hyperthermia in the presence of an alternating magnetic field. Thereby, we demonstrate a new and efficient magnetic hyperthermia strategy in which a small, but well localized, concentration of VIPs can promote an intracellular hyperthermia process.

Highlights

Over the last decades, cancer became the second major cause of death in the world[1,2]
The Vortex Iron oxide Particles (VIPs) morphology was investigated by field emission scanning electron microscopy (FESEM) and the particle size distribution was obtained by measuring the height, internal and external diameter of at least 400 particles
X-ray diffraction (XRD) and X-ray absorption near edge spectroscopy (XANES) experiments were performed to probe the crystallographic structure and chemical composition along the VIP synthesis. These results are presented in the Supporting Information (Figures S2 and S3) and indicate that the obtained VIPs are mostly composed of magnetite

Summary

Introduction

Cancer became the second major cause of death in the world[1,2]. Several therapies were developed and are still under continuous improvement[3,4,5,6,7,8,9] In this scenario, one of the most promising cancer therapies is based on the use of magnetic nanomaterials[10,11] which can be specially designed for localized hyperthermia[12,13]. One of the most promising cancer therapies is based on the use of magnetic nanomaterials[10,11] which can be specially designed for localized hyperthermia[12,13] This strategy explores the magnetic induction heating through an alternating magnetic field together with the fact that tumor cells are more heat sensitive than healthy cells[14]. The internalization phenomena of the VIP resulted in intracellular hyperthermia, allowing us to conclude that the VIP when compared to traditional SPION would be a much more localized and efficient particle for magnetic hyperthermia

Methods

Results

Conclusion