Abstract
Electromagnetic navigational bronchoscopy has been the dominant bronchoscopic technology for targeting small peripheral lesions and now includes digital tomosynthesis-electromagnetic navigational bronchoscopy (DT-ENB), allowing near-real-time intraprocedural nodule visualization. Shape-sensing robotic-assisted bronchoscopy (ssRAB), with improved catheter stability and articulation recently became available. Although the diagnostic performance of these two methods seems higher than that of legacy systems, data remain limited. We sought to compare the diagnostic yield of these two novel platforms after their introduction at our institution. Does the diagnostic yield of ssRAB differ significantly from that of DT-ENB in patients undergoing biopsy of peripheral pulmonary lesions (PPLs)? This retrospective comparative cohort study analyzed prospectively collected data on consecutive procedures performed with DT-ENB and ssRAB in their first 6months of use at our institution. Biopsies were considered diagnostic if histopathologic analysis revealed malignancy or specific benign features that readily explained the presence of a PPL. Nonspecific inflammation, normal lung or airway, and atypia not diagnostic of malignancy were considered nondiagnostic. SSRAB was used to biopsy 143 PPLs in 133 patients and DT-ENB was used to biopsy 197 PPLs in 170 patients. Diagnostic yield was 77%for ssRAB (110 of 143 PPLs) and 80%(158 of 197 PPLs) for DT-ENB (OR, 0.8; 95%CI, 0.5-1.4; P= .4). Median lesion diameters were 17 and 19mm, respectively. No difference in diagnostic yield was found after adjustment for lesion size, bronchus sign, peripheral vsmiddle third location, and sex. Pneumothorax complicated 1.5%of ssRAB and 1.8%of DT-ENB procedures (P= .86). SSRAB and DT-ENB showed comparable diagnostic yields and safety profiles in this comparative cohort study.
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