Abstract
Octadecylsilane (C18) stationary phases for liquid chromatography (LC), which are prepared by polymeric rather than monomeric phase synthesis, exhibit shape selectivity for isomeric polycyclic aromatic hydrocarbons (PAH) that is similar to the shape selectivity observed for liquid crystalline phases in gas chromatography (GC). Relative retention measurements for several sets of isomeric PAH on a polymeric C18 stationary phase (reversed-phase LC) and liquid-crystalline polysiloxane stationary phase (capillary GC) were compared and correlated with the simple length-to-breadth shape descriptor of the solute. Similar retention behavior was observed for both chromatographic systems. In fact, anomalies in elution order relative to length-to-breadth ratios were generally found to be consistent in both chromatographic systems and could often be ascribed to secondary shape factors (i.e., planarity of the molecule).
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