Abstract
We have successfully characterized the structure of testosterone, one of the essential steroids, through high-resolution rotational spectroscopy. A single conformer has been detected, and a total of 404 transitions have been fitted, allowing a precise determination of the rotational constants. It allowed us to unravel that the isolated structure of testosterone adopts an extended disposition. The results obtained in this work highlight how using laser ablation techniques in combination with Fourier transform microwave techniques allow the study of large biomolecules or common pharmaceuticals. It is an important step toward studying relevant biomolecules and developing new analytical techniques with unprecedented sensitivity and resolution.
Highlights
We have successfully characterized the structure of testosterone, one of the essential steroids, through high-resolution rotational spectroscopy
It regulates sex drive, fat distribution, body hair, bone mass, muscle mass, and red blood cells in humans. It plays a crucial role in sperm production and developing male reproductive tissues such as the testes and prostate. It is biosynthesized from cholesterol through a series of steps, and a small amount of circulating testosterone is transformed into estradiol, a form of estrogen
Nuclear magnetic resonance (NMR) spectroscopic studies have been conducted.[5,6]. These high-resolution studies conducted under the solid-state 13C nuclear magnetic resonance (NMR) technique show the existence of two species
Summary
Iker León − Grupo de Espectrocopía Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Unidad Asociada CSIC, Parque Científico UVa, Universidad de Valladolid, 47011 Valladolid, Spain; orcid.org/0000-0002-1992-935X; Email: Iker.leon@ uva.es. Alonso − Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940 Leioa, Spain; Departamento de Química Física, Facultad de Ciencia y Tecnología, Universidad del País Vasco, 48940 Leioa, Spain; orcid.org/0000-0001-5816-4102. Santiago Mata − Grupo de Espectrocopía Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Unidad Asociada CSIC, Parque Científico UVa, Universidad de Valladolid, 47011 Valladolid, Spain; orcid.org/0000-0002-1892-5015. Alonso − Grupo de Espectrocopía Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Unidad Asociada CSIC, Parque Científico UVa, Universidad de Valladolid, 47011 Valladolid, Spain; orcid.org/0000-0002-3146-8250.
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