Abstract
This research discusses the influence of morphology of nanomagnetic materials (one-dimensional iron nanowires and zero-dimensional iron nanoparticles) on heating efficiency of the hyperthermia treatment. One-dimensional iron nanowires, synthesized by reducing method in external magnetic field, are explored in terms of their material properties, magnetic anisotropy, and cytotoxicity of EMT-6 cells. The magnetic anisotropy of an array of nanowires is examined in parallel and perpendicular magnetic fields by VSM. For the magnetic hyperthermia treatment tests, iron nanowires and nanoparticles with different concentrations are heated in alternating magnetic field to measure their actual heating efficiency and SLP heating properties. The shape effects of iron nanomaterials can be revealed from their heating properties. The cytotoxicity of nanowires with different concentrations is measured by its survival rate in EMT-6 with the cells cultivated for 6 and 24 hours.
Highlights
According to the World Health Organization (WHO), cancers were the top causes of death all over the world
This research is focused on the magnetic targeted hyperthermia treatments
Magnetic targeted hyperthermia treatments are conducted by placing magnetic targeted medicines on the tumor and imposing the alternating magnetic field (∼kHz–∼MHz) on it [7, 8]
Summary
According to the World Health Organization (WHO), cancers were the top causes of death all over the world. To generate heat in an alternating field, magnetic materials activate more than four different known mechanisms, which are generation of eddy currents, hysteresis losses, relaxation losses, and frictional losses, and so forth. Similar to the hysteresis loss in multidomain magnetic particles, the Neel mechanism can generate heat by means of “internal friction” caused by the movement of the magnetic moment in an external field. The whole particle moves towards the external field with the moment locked along the crystal axis instead This phenomenon serves to account for the mechanical friction component in a given suspending medium. The factors that affect the biodistribution of polymeric iron nanoparticles (NPs) include the size, shape, hydrophobic/hydrophilic balance of the surface, and surface charge [14] This experiment explores the characteristic differences of heating effectiveness between 1D iron nanowires (NWs) and commercial iron nanoparticles (NPs) in hyperthermia treatments. The cellular toxic tests of the nanoiron are conducted for the iron NWs in further studies
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