Abstract
A type of specially designed pin model of Mg-Zn alloy was implanted into the full thickness of lesions of New Zealand rabbits’ femoral condyles. The recovery progress, outer surface healing and in vivo degradation were characterized by various methods including radiographs, Micro-CT scan with surface rendering, SEM (scanning electron microscope) with EDX (Energy Dispersive X-ray analysis) and so on. The in vivo results suggested that a few but not sufficient bridges for holding force were formed between the bone and the implant if there was a preexisting gap between them. The rapid degradation of the implantation in the condyle would result in the appearance of cavities. Morphological evaluation of the specially designed pins indicated that the cusp was the most vulnerable part during degradation. Furthermore, different implantation sites with distinct components and biological functions can lead to different degradation rates of Mg-Zn alloy. The rate of Mg-Zn alloy decreases in the following order: implantation into soft tissue, less trabecular bone, more trabecular bone, and cortical bone. Because of the complexities of in vivo degradation, it is necessary for the design of biomedical Mg-Zn devices to take into consideration the implantation sites used in clinics.
Highlights
In the investigation of biodegradable Mg based implants, it was found that the physiological parameters in the environment have different effects on their degradation behavior [1,2,3]
The inside evaluation in the femoral condyle was characterized by Micro-CT, which can display gray level according to the structural density
It is hard to tell the differences between the sizes of the cavities that belong to one-pin and two-pin implantation at the same time point
Summary
In the investigation of biodegradable Mg based implants, it was found that the physiological parameters in the environment have different effects on their degradation behavior [1,2,3]. The femoral condyle which is composed of marrow, spongy bone, compact bone and cartilage was chosen as the implantation site. One is “full thickness defect” which means that the lesion penetrates the subchondral bone. The other is called “partial thickness lesion” which means the defect does not reach the subchondral bone. The repair of both of them remains a current clinical problem. The main focus of this study is to analyze the biodegradation behavior of Mg-Zn alloy with simulated device shapes in different implantation sites
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