Abstract
Objectives: The present study was designed to assess whether changes in NT-proBNP levels after mitral, aortic and double valve replacement reflect changes in HF manifestations including NYHA class and changes in LA size, LV size and LV functions. Methods: The study population consisted of 24 patients (mean age: 55.3 ± 16.2 years, 58% were males) underwent surgical mitral valve Replacement (12 patients), Aortic valve replacement (8 patients) and combined mitral and aortic valve replacement (4 patients). Serial NT-proBNP measurements, transthoracic Echocardiography and (NYHA) class assessment were performed before and 6 months after surgery. Results: The decrease in NT-proBNP was associated with decrease in LAD (r = 0.73, p< 0.002), LVESD (r = 0.65, p= 0.001), LVED (r = 0.53, p= 0.036), and increase in EF (r = 0.65, p= 0.001). Decreasing NT-proBNP was associated with improvement in NYHAFC. Conclusion: NT-proBNP levels after mitral, aortic and double valve replacement correlate with changes in heart failure manifestations as well as changes in left atrial size and ventricular dimensions and function.
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