Abstract
The reaction of CpFe(dppe)I (Cp, cyclopentadienyl; dppe, Ph2P(CH2)2PPh2) with biologically active RSH molecules (L-cysteine hydrochloride, dithiothereitol and 2-mercaptoethanol) in the presence of NH4PF6 and in methanol as solvent afforded the new iron(III) thiolate complexes [CpFe(dppe)SR]PF6. The blue–black paramagnetic complexes were characterized by elemental analysis and IR, EPR and UV–visible spectroscopy. The selective S–H bond cleavage in the thiols suggests a possible utilization of the organometallic iron(II) complexes as inhibitors in some cysteine proteases. The spectroscopic properties of the new complexes have been compared with those of other Fe–S models as well as with Fe–S proteins. Copyright © 2000 John Wiley & Sons, Ltd.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
