Abstract
Transsexualism is characterised by the feeling of belonging to the wrong gender and the strong wish to achieve gender reassignment by hormonal and surgical treatment in combination with normal body appearance. It has been found that an androgen-dependent, sexually dimorphic nucleus in the hypothalamus which is involved in gender-specific behavior, the BSTc, has the size of females in male-to-female transsexuals (MFT). The ratio of digit 2 to digit 4 in the right hand (2D/4D ratio) has been shown to be sexually dimorphic with a smaller ratio in men than in women and to correlate negatively with testosterone and sperm count. Moreover, in patients with CAH, a condition characterized by elevated prenatal androgen levels, the 2D/4D ratio is lower. Since most sexually dimorphic feautures in the body are assumed to be regulated by prenatal testosterone levels, the D2/D4 ratio has been suggested to be a marker for prenatal testosterone exposure.
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