Abstract
PurposeErectile dysfunction (ED) and premature ejaculation (PE) are common sexual disorders in people with diabetes. Glucose variability (GV) has been recognized as a predictor of microvascular complications. The aim of this study was to investigate the relationship between glucose variability and sexual dysfunctions in young men with type 1 diabetes.MethodsOne hundred and twelve patients with type 1 diabetes, aged 18–30 years, were enrolled. Patients were divided into two groups according to glucose variability [group 1 (high GV with coefficient of variation ≥ 36%)] and group 2 (low GV with coefficient of variation < 36%)). The presence of sexual dysfunctions was investigated with validated questionnaires.ResultsED and PE prevalence rates in group 1 were 26% and 13%, respectively. Similarly, in group 2, the prevalence of ED was 24%, and the prevalence of PE was 13%. In both groups, no significant associations between sexual dysfunctions and parameters of glucose variability were found. Multiple regression analysis identified age and depression as independent predictors of ED and PE.ConclusionYoung male patients affected by type 1 diabetes with high or low glucose variability show a similar prevalence of sexual dysfunctions. ED is the most common sexual dysfunction in diabetic men. Age and depression were the only independent predictive factors for sexual dysfunctions in this population.
Highlights
Diabetes is one of the most common chronic diseases in most countries worldwide and a well-known risk factor for sexual dysfunctions in men [1]
This is a single-center, cross-sectional study aimed at evaluating the influence of glycemic variability (GV) on sexual dysfunctions in young men with type 1 diabetes admitted to the Unit of Diabetes at the Teaching Hospital of the University of Campania “Luigi Vanvitelli,” Naples, Italy
Sixty-eight men were treated with multiple daily injections of insulin (MDI), while the remaining 44 patients were on continuous subcutaneous insulin infusion (CSII)
Summary
Diabetes is one of the most common chronic diseases in most countries worldwide and a well-known risk factor for sexual dysfunctions in men [1]. ED is a common sexual arousal disorder in men with diabetes [3], a threefold increased risk having been documented in the Massachusetts. Male Aging Study [4] as compared to nondiabetic men. ED generally occurs 10–15 years sooner in men with diabetes [4] than in those who do not suffer from diabetes and is more severe [5] and less responsive to oral drugs [6, 7], leading to a reduction in quality of life [5, 8]. Whether hyperglycemia is a risk factor for the development of ED in diabetic men is still not clear. Some observational studies have shown a relationship between poor glycemic control, expressed by elevated levels of glycated hemoglobin ( HbA1c) and ED [5, 9, 10], whereas other studies did not report any association [11]
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