Abstract
Meiosis is a highly conserved and essential process in gametogenesis in sexually reproducing organisms. However, there are substantial sex-specific differences within individual species with respect to meiosis-related chromatin reorganization, recombination, and tolerance for meiotic defects. A wide range of murine models have been developed over the past two decades to study the complex regulatory processes governing mammalian meiosis. The present review article thus provides a comprehensive overview of the knockout mice that have been employed to study meiosis, with a particular focus on gene- and gametogenesis-related sexual dimorphism observed in these model animals. In so doing, we aim to provide a firm foundation for the future study of sex-specific differences in meiosis at the molecular level.
Highlights
For mammalian species, life begins when haploid egg and sperm cells fuse with one another
Meiosis is a tightly conserved mammalian biological process that is essential to the generation of male and female gametes, but a high degree of sexual dimorphism exists in the specific regulation of such gametogenesis
Clear differences in the regulation and characteristics of meiotic onset and duration are observed between the sexes (Figure 1)
Summary
Reviewed by: Shuiqiao Yuan, Huazhong University of Science and Technology, China Jeremy Wang, University of Pennsylvania, United States
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
