Abstract

The aim of this review is to systematize and generalize reported data characterizing the involvement of the monoaminergic systems of the brain and sex steroids in the regulation/modulation of the functions of the amygdaloid complex. The characteristics of the noradrenergic, dopaminergic, and serotoninergic systems and their representations in the amygdaloid complex are described. The actions of noradrenaline, dopamine, and serotonin on its neurons have been shown to be mediated via the corresponding cellular receptors under the modulatory influence of sex steroids. The combined involvement of monoamines and sex steroids occurs in the regulation of the activity of the cyclic center for the secretion and release of gonadotropins and constitutes the basis for the formation of adaptive (sexual, feeding, and aggressivedefensive) behavior, including stress reactions. These data may be useful for understanding the influences of the sex factor on human personality characteristics, cognitive abilities, and behavioral responses, and may also find applications in the development of optimal medications for use in the clinical management of psychoneurological diseases.

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