Abstract
OBJECTIVETo evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition.RESEARCH DESIGN AND METHODSA randomized clinical trial was performed to create contrasting sex steroid levels in healthy young men: by letrozole (aromatase inhibitor) to lower estradiol (E2) and increase testosterone (group T, n = 10) versus letrozole plus E2 patches to lower T and raise E2 (group E, n = 10). Mixed meals and hyperinsulinemic-euglycemic clamps were performed before and after a 1-week treatment period.RESULTSFollowing intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E.CONCLUSIONSIn healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity.
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