Abstract
Background and Aims : Fibro-calcific aortic valve disease (FCAVD) is a highly prevalent valvular disorder, associated with high morbidity and mortality. Fibrotic extracellular matrix (ECM) remodeling and calcific mineral deposition disturb valvular microarchitecture and function. Recent data suggest phenotypic differences in female and male FCAVD patients. Females have a higher contribution of fibrosis. Males have a more calcific phenotype. Here we investigated the role of donor sex in a FCAVD in vitro model.
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