Abstract
Extended embryo culture during in-vitro fertilization (IVF) is associated with an increased risk of adverse perinatal outcomes such as preterm delivery in fresh cycles. While utilization of vitrified/warmed blastocyst embryo transfers (FET) has increased, the impact of subtle differences in embryo development kinetics on perinatal outcomes is unknown. In addition, increasing evidence supports sex-specific variations in early human embryo development, suggesting the impact of extended embryo culture on perinatal outcomes may be dimorphic.
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