Sex-specific association between soluble corin and metabolic syndrome in Chinese adults.

Abstract

Soluble corin has been associated with cardiovascular disease and its risk factors, but whether it is associated with metabolic syndrome (MetS), a cluster of cardiometabolic disorders, remains unclear. We aimed to examine the association between soluble corin and MetS in Chinese men and women. We examined serum soluble corin using immunoassays in 962 men (mean age, 53 years) and 1536 women (mean age, 54 years) free of cardiovascular disease. Logistic regression was applied to examine the association between soluble corin and MetS in men and women. The results showed that participants in the 3rd and 4th quartiles of serum soluble corin had 1.99 (95% CI: 1.32-3.00) and 3.84 (95% CI: 2.54-5.83) times the risk of having MetS for men and 1.48 (95% CI: 1.06-2.06) and 1.53 (95% CI: 1.10-2.12) times the risk of having MetS for women compared to those in the lowest quartile. The magnitude of the association between serum soluble corin and MetS was significantly stronger for men than for women (P < 0.001). These results indicated that soluble corin was significantly associated with MetS, and this association was stronger for men than for women. Corin may contribute to cardiometabolic risks differently between men and women and thereby accounting, at least partly, for the sex difference in cardiovascular risk.