Sex-speciﬁc in the relationship between hyperuricemia and pulse pressure in non-diabetic Korean adults: the 2017 Korean National Health and Nutrition Examination Survey

Kyu Eun Lee ,Cho-Hee Park ,Jae Sung Lee ,Chang Gi Kong ,Hyun Ju Yoon

doi:10.31083/jomh.2021.064

Abstract

Background and objective: The present study assesses the relationship between hyperuricemia and pulse pressure (PP) in non-diabetic Korean adults. Material and methods: Data from 5122 subjects (2251 men and 2871 women) in the seventh Korean National Health and Nutrition Examination Survey (KNHANES VII-2, 2017) were analyzed. Results: Systolic blood pressure (SBP) and PP were signiﬁcant factors determining the odds ratios (ORs) for hyperuricemia (uric acid ≥7.0 mg/dL in men or ≥6.0 mg/dL in women) in men and the overall population. In women, SBP, diastolic blood pressure (DBP), and PP were not signiﬁcant factors determining the OR for hyperuricemia. After adjusting for related variables, the OR of hyperuricemia was signiﬁcantly higher in the high PP group (PP >60.0 mmHg) for men (OR, 1.760; 95% conﬁdence interval [CI], 1.152--2.688) and the overall population (OR, 1.557; 95% CI, 1.132--2.140) compared with the normal PP group, but this trend was not seen in women (OR, 1.060; 95% CI, 0.646--1.740). Conclusions: Hyperuricemia was positively associated with PP in non-diabetic Korean men but not in women.

Highlights

High systolic blood pressure (SBP) affects cardiac structure and function and is associated with chronic left ventricular (LV) overload and ventricular remodeling [1, 2]
Systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), waist circumference (WC), TGs, fasting blood glucose (FBG), blood urea nitrogen (BUN), Crea, hs C reactive protein (CRP), and Uric acid (UA) were higher in men than in women, total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were lower in men than in women, and pulse pressure (PP) was not significant
3.2 Clinical characteristics of subjects according to normouricemia and hyperuricemia groups in men, women, and the overall population

Summary

Introduction

High systolic blood pressure (SBP) affects cardiac structure and function and is associated with chronic left ventricular (LV) overload and ventricular remodeling [1, 2]. Hyperuricemia, defined as a serum UA concentration of ≥7.0 mg/dL in men and ≥6.0 mg/dL in women [9], is an independent risk factor for cardiovascular disease and is associated with diabetes, metabolic syndrome, hypertension, and chronic kidney disease in high-risk populations [10,11,12]. The present study assesses the relationship between hyperuricemia and pulse pressure (PP) in non-diabetic Korean adults. Results: Systolic blood pressure (SBP) and PP were significant factors determining the odds ratios (ORs) for hyperuricemia (uric acid ≥7.0 mg/dL in men or ≥6.0 mg/dL in women) in men and the overall population. SBP, diastolic blood pressure (DBP), and PP were not significant factors determining the OR for hyperuricemia. Conclusions: Hyperuricemia was positively associated with PP in non-diabetic Korean men but not in women

Methods

Results

Discussion

Conclusion