Abstract
Platelet lipid composition, 1–14C arachidonic acid (AA) metabolism by platelets (stimulated with thrombin), serum thromboxane (Tx)B 2 production and plasma lipid composition were investigated in 53 healthy females (18–45 years) and 65 males (19–45 years) with similar dietary habits. In males, serum TxB 2 production and cholesterol platelet membrane levels were found significantly higher (p<0.001 and p<0.05) than in females. No differences were observed between the two groups in the AA conversion through cyclo-oxygenase and lipoxygenase pathways or in the platelet phospholipid fatty acid composition. These findings indicate that in males the platelet proaggregatory capacity is greater than in females and the higher platelet TxB 2 production does not depend on a larger AA availability or on enzyme activation for its conversion. The increased TxB 2 production may be, at least in part, induced by functional differences such as a different membrane cholesterol content inducing, in its turn, an increased microviscosity and/or higher number of platelet receptors for thrombin.
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