Abstract
The sex ratio at birth was examined in offsprings of rats reared in 5°C for successive generations. The sex ratio of their offsprings significantly skewed toward females and the litter size markedly reduced, as compared with those of controls reared in 22°C. Continuous administration of norepinephrine for 12 weeks which purports to simulate a cold stress resulted in a reduction of litter size with a tendency of skewness in sex ratio toward females.
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