Abstract
We have examined the transmission of the supratype associated with C2 deficiency (C2Q0) using our own and many published pedigrees in order to determine whether nonrandom transmission may contribute to the stability of disease-associated supratypes. Unexpectedly, we found that C2Q0 may be preferrentially transmitted to the opposite sex and therefore propose that such “zig-zag” transmission may result in the presentation of recessive disease susceptibility genes and in the maintenance of heterozygosity. Further pedigrees are required to verify our findings.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
