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Abstract
Sex, gender and immunosenescence: a key to understand the different lifespan between men and women?
Highlights
Gender and sex are known to be associated with longevity
It is well known that female mithocondria produce less reactive oxygen species than male ones and that estrogens increase high density lipoproteins and decrease low density ones [5,6]. Both gender and sex might be responsible for the differences in lifespan between males and females [2,3]
To elucidate the relationship between immunological changes and lifespan, peripheral blood mononuclear cells of 356 healthy Japanese ranging in age from 20 to 90 years were analyzed for the number and percentage of various lymphocytes by using three color flow cytometry [8]
Summary
Gender and sex are known to be associated with longevity. While males are usually stronger, females live longer. Both gender and sex might be responsible for the differences in lifespan between males and females [2,3]. Immune-inflammatory responses play a key role in successful ageing [2]. It is still controversial whether agerelated changes of immune system are different between men and women.
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