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Abstract
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination and early diagnosis of hepatoma, complications of hepatoma, and their preventions and treatments, etc.
Highlights
Hepatocellular carcinoma (HCC), the most common primary liver cancer (PLC), carries an ominous prognosis, and is the fourth most common cause of mortality owing to cancer[1,2]
The proportion of HCCs attributed to nonalcoholic fatty liver disease (NAFLD) is increasing owing to trajectories of declining HCV infection and escalating NAFLD[1,3,4]
The keywords used in our search include, but are not limited to: HCC, liver cancer, sex differences, gender differences, epidemiology, natural course, pathogenesis, risk factors, immune response, genetics, and sex hormones
Summary
Hepatocellular carcinoma (HCC), the most common primary liver cancer (PLC), carries an ominous prognosis, and is the fourth most common cause of mortality owing to cancer[1,2]. The chief modifiers of HCC risk include geographic variability, demographics and severity of liver disease[2]. Irrespective of aetiology, increases the risk of HCC[1]. The proportion of HCCs attributed to nonalcoholic fatty liver disease (NAFLD) is increasing owing to trajectories of declining HCV infection and escalating NAFLD[1,3,4]. Additional risk factors for the development of HCC are infection with HBV, alcoholic liver disease, aflatoxin, and genetic haemochromatosis[5]. Similar to HCC, NAFLD accounts for a substantial clinical burden and exacts a heavy toll of healthcare-related expenses[8]
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